聯絡資訊
電子郵件信箱 chou0217@tmu.edu.tw
連絡電話 (02)2736-1661#3257
實驗室介紹
本實驗室以觀察動物組織型態的相關實驗技術進行研究為主，包括一般動物組織製備進行型態觀察、動物組織經免疫組織化學染色進行特異性型態觀察、電子顯微鏡觀察細胞的超微結構型態。
實驗室研究方向
目前實驗室執行的實驗多為以動物模式印證人類因母體影響造成新生兒出生前後可能產生的疾病變化及出生後高氧治療下可能引起的新生兒病變
重要獎項與榮譽
- 108學年度醫學院教學優良教師
學歷
- 國立臺灣大學解剖學暨細胞生物學研究所 博士
- 國立臺灣大學解剖學研究所 碩士
- 臺北醫學院保健營養學系 學士
經歷
- 解剖學暨細胞生物學科教授
- 解剖學暨細胞生物學科副教授
研究專長
- 免疫組織化學 immunohistochemistry
- 組織學技術 technical of histology
- 電子顯微鏡技術 technical of EM
發表論文 (五年內)
- Chen BJ, Yuan CT, Yang CF, Ho CH, Lin YK, Su YZ, Chou HC, Chuang SS. 2022 Jun 3. Plasmablastic myeloma in Taiwan frequently presents with extramedullary and extranodal mass mimicking plasmablastic lymphoma. Virchows Arch. doi: 10.1007/s00428-022-03342-3. Online ahead of print. PMID: 35657404
- Chou HC, Chen CM. 2022 Mar 26. Hyperoxia Induces Ferroptosis and Impairs Lung Development in Neonatal Mice. Antioxidants (Basel) 26;11(4):641. doi: 10.3390/antiox11040641. PMID: 35453326
- Lee YG, Chou HC, Chen YT, Tung SY, Ko TL, Buyandelger B, Wen LL, Juan SH. 2022 Mar 18. L-Carnitine reduces reactive oxygen species/endoplasmic reticulum stress and maintains mitochondrial function during autophagy-mediated cell apoptosis in perfluorooctanesulfonate-treated renal tubular cells. Sci Rep. 18;12(1):4673. doi: 10.1038/s41598-022-08771-3. PMID: 35304586
- Huang LT, Chou HC, Chen CM. 2022 Feb. Inhibition of FABP4 attenuates hyperoxia-induced lung injury and fibrosis via inhibiting TGF-β signaling in neonatal rats. J Cell Physiol. 237(2):1509-1520. doi: 10.1002/jcp.30622. Epub 2021 Oct 28. PMID: 34708870
- Huang LT, Chou HC, Chen CM. 2021 Jul. Roxadustat attenuates hyperoxia-induced lung injury by upregulating proangiogenic factors in newborn mice. Pediatr Neonatol. 62(4):369-378. doi: 10.1016/j.pedneo.2021.03.012. Epub 2021 Mar 24. PMID: 33865748.
- Lo YC, Chen KY, Chou HC, Lin IH, Chen CM. 2021 Mar 1. Neonatal hyperoxia induces gut dysbiosis and behavioral changes in adolescent mice. J Chin Med Assoc. 84(3):290-298. doi: 10.1097/JCMA.0000000000000488. PMID: 33496514.
- Chen CM, Chou HC, Yang YSH, Su EC, Liu YR. 2021. Predicting Hyperoxia-Induced Lung Injury from Associated Intestinal and Lung Dysbiosis in Neonatal Mice. Neonatology. 118(2):163-173. doi: 10.1159/000513553. Epub 2021 Mar 5. PMID:33677454.
- Tsai CY, Chou HC, Chen CM. 2021 Apr 15. Perinatal nicotine exposure alters lung development and induces HMGB1-RAGE expression in neonatal mice. Birth Defects Res. 113(7):570-578. doi: 10.1002/bdr2.1840. Epub 2020 Nov 9. PMID:33166075.
- Chen CM, Chou HC, Yang YSH. 2021 Jun 4. Maternal Antibiotic Treatment Disrupts the Intestinal Microbiota and Intestinal Development in Neonatal Mice. Front Microbiol. 12:684233. doi: 10.3389/fmicb.2021.684233. PMID: 34177871; PMCID: PMC8220820.
- Chen CM, Yang YSH, Chou HC. 2021 Oct. Maternal antibiotic exposure disrupts microbiota and exacerbates hyperoxia-induced lung injury in neonatal mice. Pediatr Res. 90(4):776-783. doi: 10.1038/s41390-020-01335-z. Epub 2021 Jan 19. PMID:33469177.
- Chen CM, Hwang J, Chou HC. 2021 Feb. Immunization with anti-Tn immunogen in maternal rats protects against hyperoxia-induced kidney injury in newborn offspring. Pediatr Res. 89(3):476-482. doi: 10.1038/s41390-020-0894-6. Epub 2020 Apr 20. PMID: 32311698.
- Chen XY, Feng PH, Han CL, Jheng YT, Wu CD, Chou HC, Chen YY, Wu SM, Lee KY, Kuo HP, Chung KF, Hsiao TC, Chen KY, Ho SC, Chang TY, Chuang HC. Alveolar epithelial inter-alpha-trypsin inhibitor heavy chain 4 deficiency associated with senescence-regulated apoptosis by air pollution. Environ Pollut. 2021 Jun 1;278:116863. doi: 10.1016/j.envpol.2021.116863. Epub 2021 Mar 9. PMID:33735794.
- Huang LT, Chou HC, Chen CM. 2021 Oct 28. Inhibition of FABP4 attenuates hyperoxia-induced lung injury and fibrosis via inhibiting TGF-β signaling in neonatal rats. J Cell Physiol. doi: 10.1002/jcp.30622. Epub ahead of print. PMID:34708870.
- Chow JC, Chou HC, Hwang J, Chen CM. 2021 Oct 21. Anti-Tn Monoclonal Antibody Ameliorates Hyperoxia-Induced Kidney Injury by Suppressing Oxidative Stress and Inflammation in Neonatal Mice. Mediators Inflamm. 2021:1180543. doi: 10.1155/2021/1180543. PMID: 34720748; PMCID: PMC8553484.
- Wen LL, Chen YT, Lee YG, Ko TL, Chou HC, Juan SH. 2021 Jan 20. Perfluorooctane sulfonate induces autophagy-associated apoptosis through oxidative stress and the activation of extracellular signal-regulated kinases in renal tubular cells. PLoS One. 16(1):e0245442. doi: 10.1371/journal.pone.0245442. PMID:33471797; PMCID: PMC7817024.
- Jheng YT, Putri DU, Chuang HC, Lee KY, Chou HC, Wang SY, Han CL. 2021 Jun 25. Prolonged exposure to traffic-related particulate matter and gaseous pollutants implicate distinct molecular mechanisms of lung injury in rats. Part Fibre Toxicol. 18(1):24. doi: 10.1186/s12989-021-00417-y. PMID: 34172050; PMCID:PMC8235648.
- Chuang HC, Chen YY, Hsiao TC, Chou HC, Kuo HP, Feng PH, Ho SC, Chen JK, Chuang KJ, Lee KY. 2020 Oct 5. Alteration in angiotensin-converting enzyme 2 by PM1 during the development of emphysema in rats. ERJ Open Res. 6(4):00174-2020. doi: 10.1183/23120541.00174-2020. PMID: 33043050; PMCID: PMC7533376.
- Chou HC, Chang CH, Chen CH, Lin W, Chen CM. 2021 May 1. Consecutive daily administration of intratracheal surfactant and human umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced lung injury in neonatal rats. Stem Cell Res Ther. 12(1):258. doi: 10.1186/s13287-021-02335-4. PMID: 33933128; PMCID: PMC8088571.
- Chen XY, Chen YY, Lin W, Chen CH, Wen YC, Hsiao TC, Chou HC, Chung KF, Chuang HC. 2021 Sep 27. Therapeutic Potential of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Recovering From Murine Pulmonary Emphysema Under Cigarette Smoke Exposure. Front Med (Lausanne). 8:713824. doi: 10.3389/fmed.2021.713824. PMID: 34646841; PMCID: PMC8502916.
- Huang LT, Chou HC, Chen CM. 2021 Jan 1. TRIM72 mediates lung epithelial cell death upon hyperoxia exposure. J Chin Med Assoc. 84(1):79-86. doi: 10.1097/JCMA.0000000000000413. PMID: 32796321
- Tsai CY, Chou HC, Chen CM. 2020 Nov 9. Perinatal nicotine exposure alters lung development and induces HMGB1-RAGE expression in neonatal mice. Birth Defects Res. doi: 10.1002/bdr2.1840. Online ahead of print. PMID: 33166075
- Chuang HC, Chen YY, Hsiao TC, Chou HC, Kuo HP, Feng PH, Ho SC, Chen JK, Chuang KJ, Lee KY. 2020 Oct 5 Alteration in angiotensin-converting enzyme 2 by PM1 during the development of emphysema in rats. ERJ Open Res. 6(4):00174-2020. doi: 10.1183/23120541.00174-2020. eCollection 2020 Oct. PMID: 33043050.
- Chen CM, Hwang J, Chou HC, Chen C. 2020 Sep 8. Anti-Tn Monoclonal Antibody Attenuates Hyperoxia-Induced Lung Injury by Inhibiting Oxidative Stress and Inflammation in Neonatal Mice. Front Pharmacol. 11:568502. doi: 10.3389/fphar.2020.568502. eCollection 2020.PMID: 33013407.
- Chou HC, Chen CM. 2020 Oct. Human placenta-derived mesenchymal stem cells attenuate established hyperoxia-induced lung injury in newborn rats. Pediatr Neonatol. 61(5):498-505. doi: 10.1016/j.pedneo.2020.05.012. Epub 2020 Jun 3. PMID: 32564932.
- Lee JC, Chou HC, Wang CH, Chu PY, Hsieh TH, Liu ML, Hsieh SM, Liu YR, Kao YC. 2020 Mar. Myoepithelioma-like Hyalinizing Epithelioid Tumors of the Hand With Novel OGT-FOXO3 Fusions. Am J Surg Pathol. 44(3):387-395. doi:10.1097/PAS.0000000000001380. PMID: 31567281
- Jiang JS, Chou HC, Chen CM. 2020 Apr. Cathelicidin attenuates hyperoxia-induced lung injury by inhibiting oxidative stress in newborn rats. Free Radic Biol Med. 150:23-29. doi: 10.1016/j.freeradbiomed.2020.02.005. Epub 2020 Feb 11. PMID: 32057991
- Chou HC, Chen CM. 2019 Nov. Cathelicidin attenuates hyperoxia-induced kidney injury in newborn rats.Ren Fail. 41(1):733-741. doi: 10.1080/0886022X.2019.1651741. PMID: 31424299
- Wu CS, Chou HC, Huang LT, Lin CM, Lin YK, Chen CM. 2019 Oct. High amplitude bubble continuous positive airway pressure decreases lung injury in rats with ventilator-induced lung injury. J Chin Med Assoc. 82(10):795-801. doi: 10.1097/JCMA.0000000000000070. PMID: 30893255
- Chou HC, Chen CM. 2020 Apr. Cathelicidin attenuates hyperoxia-induced intestinal injury through inhibition of NF-κB activity in newborn rats. Exp Mol Pathol. 113:104269. doi: 10.1016/j.yexmp.2019.104269. Epub 2019 Jun 14. PMID: 31202738
- Lin SC, Chou HC, Chen CM, Chiang BL. 2019 Aug.Insights Figure for Anti-thymic stromal lymphopoietin antibody suppresses airway remodeling in asthma through reduction of MMP and CTGF. Pediatr Res. 86(2):285. doi: 10.1038/s41390-019-0457-x. Epub 2019 Jun 13. PMID: 31195404
- Chen CM, Chou HC. 2019 Aug. Maternal inflammation exacerbates neonatal hyperoxia-induced kidney injury in rat offspring. Pediatr Res. 86(2):174-180. doi: 10.1038/s41390-019-0413-9. Epub 2019 May 13. PMID: 31086293
- Chen CM, Hwang J, Chou HC. 2019 Apr 4. Maternal Tn Immunization Attenuates Hyperoxia-Induced Lung Injury in Neonatal Rats Through Suppression of Oxidative Stress and Inflammation. Front Immunol. 10:681. doi: 10.3389/fimmu.2019.00681. eCollection 2019. PMID: 31019509
- Lin SC, Chou HC, Chen CM, Chiang BL. 2019 Aug. Anti-thymic stromal lymphopoietin antibody suppresses airway remodeling in asthma through reduction of MMP and CTGF. Pediatr Res. 86(2):181-187. doi: 10.1038/s41390-018-0239-x. Epub 2018 Nov 21. PMID: 30464333
- Chen CM, Chou HC. 2018 Aug 15. Human mesenchymal stem cells attenuate hyperoxia-induced lung injury through inhibition of the renin-angiotensin system in newborn rats. Am J Transl Res. 10(8):2628-2635. eCollection 2018. PMID: 30210699.
- Chen CM, Juan SH, Chou HC. 2018 Jul-Sep. Hyperglycemia activates the renin-angiotensin system and induces epithelial-mesenchymal transition in streptozotocin-induced diabetic kidneys. J Renin Angiotensin Aldosterone Syst. 19(3):1470320318803009. doi: 10.1177/1470320318803009. PMID: 30264671.
- Chen CM, Juan SH, Pai MH, Chou HC. 2018 Aug. Hyperglycemia induces epithelial-mesenchymal transition in the lungs of experimental diabetes mellitus. Acta Histochem. 120(6):525-533. doi: 10.1016/j.acthis.2018.06.004. Epub 2018 Jun 20. PMID: 29934127
- Chen CM, Hwang J, Chou HC, Shiah HS. 2018 Jun. Tn (N-acetyl-d-galactosamine-O-serine/threonine) immunization protects against hyperoxia-induced lung injury in adult mice through inhibition of the nuclear factor kappa B activity. Int Immunopharmacol. 59:261-268. doi: 10.1016/j.intimp.2018.04.022. Epub 2018 Apr 15. PMID: 29669308
